If syphilis is diagnosed and treated in its early stages it is easy to be cured. Penicillin is the preferred treatment in all of its stages, an antibiotic that kills the organism causing syphilis. If the patient is allergic to Penicillin another antibiotic can be used.

A simple Penicillin injection can stop the progress of the disease if the patient was infected within the last year. μπορεί να σταματήσει την πρόοδο της νόσου αν ο ασθενής έχει μολυνθεί μέσα στον τελευταίο χρόνο. Otherwise more doses may be needed.

Penicillin is the only recommended treatment for pregnant women suffering from syphilis. Those who are allergic to Penicillin can undergo desensitization, which will allow them to receive the medicine without side effects. In case if a pregnant receives syphilis treatment antibiotics must also be administered to the baby.

On the first day of administration the patient is likely to manifest a Jarisch-Herxheimer reaction. Symptoms include fever, ague, nausea, acute pain and headaches. This reaction usually does not last for more than 24 hours.