Sweet syndrome

by Dr. Yiannis Neofytou

Sweet’s syndrome is characterized by sudden onset of fever, leukocytosis, and tender, raised, erythematous, and well-circumscribed papules and plaques, histologically composed of neutrophilic infiltrates. Sweet’s syndrome primarily affects adults and occurs three times more frequently in women than in men. The lesions may have a strongly edematous appearance (first image) or simply be infiltrated (second image). They are usually found on the face, neck, upper trunk and extremities.They are characterized by a burning sensation but not itching. Vesiculation or pustular development may occur on the surface of the plaques as a result of an intense choroidal inflammatory infiltrate and accompanying choroidal edema. The condition may resolve spontaneously or be managed with topical or systemic steroids.

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