The exact causes of the disease are not fully understood, but it became well known that chronic atopic dermatitis is a combination of interactions between :
- Distorted operation of the skin barrier
- Immunological factors
- Environmental factors
- Genetic predisposition
- Further there are some allergizing agents which affect a flare of the disease such as:
- Woolen clothes from rough fabrics
- Plants and pollen
- Bleach and other chemical agents