- Persons with neuromuscular disaeases (myasthenia Gravis, Eaton – Lambert syndrom)
- Allergy in one of the ingredients of the product or inflammation in the application area
- Medication acting on the neuro muscular junctions thereby increasing the efficiency of botulinum toxin (aminoglycosides, penicillamin, quinine, calcium channel blockers)
- Pregnancy and breastfeeding
