The low temperature of the tissue is usually achieved through the use of liquid nitrogen. Liquid nitrogen is usually kept in special containers.

During the contact of liquid nitrogen to the skin , through spraying or contact probes freezing if the skin is caused .

Soon swelling and redness are created in the area and in some cases by next day a blister is formed. Subsequently a scab is formed (crust) which detaches in 7 -12 days, depending on the treatment.